CATH Domain 4ogyA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.34

Plasma kallikrein.

based on mapping to UniProt P03952

Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.

-!- Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. -!- Activates coagulation factors XII, VII and plasminogen. -!- Selective for Arg > Lys in P1, in small molecule substrates. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.21 and EC 3.4.21.8.

UniProtKB Entries (1)

S6C4R2

S6C4R2_HUMAN

Homo sapiens

IgG H chain

PDB Structure

PDB	4OGY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of plasma kallikrein by a highly specific active site blocking antibody. Kenniston, J.A., Faucette, R.R., Martik, D., Comeau, S.R., Lindberg, A.P., Kopacz, K.J., Conley, G.P., Chen, J., Viswanathan, M., Kastrapeli, N., Cosic, J., Mason, S., DiLeo, M., Abendroth, J., Kuzmic, P., Ladner, R.C., Edwards, T.E., TenHoor, C., Adelman, B.A., Nixon, A.E., Sexton, D.J. J.Biol.Chem.