CATH Domain 4oclB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.140	Cytidine Deaminase; domain 2
	3.40.140.10	Cytidine Deaminase, domain 2

Domain Context

CATH Clusters

Superfamily	Cytidine Deaminase, domain 2
Functional Family	26S proteasome non-ATPase regulatory subunit

Enzyme Information

3.4.19.12

Ubiquitinyl hydrolase 1.

based on mapping to UniProt P43588

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

P43588

RPN11_YEAST

Saccharomyces cerevisiae S288C

Ubiquitin carboxyl-terminal hydrolase RPN11

PDB Structure

PDB	4OCL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11. Pathare, G.R., Nagy, I., Sledz, P., Anderson, D.J., Zhou, H.J., Pardon, E., Steyaert, J., Forster, F., Bracher, A., Baumeister, W. Proc.Natl.Acad.Sci.USA