CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.590 | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
Domain Context
CATH Clusters
| Superfamily | Alpha-ketoglutarate-dependent dioxygenase AlkB-like |
| Functional Family | RNA demethylase ALKBH5 |
Enzyme Information
| 1.14.11.53 |
mRNA N(6)-methyladenine demethylase.
based on mapping to UniProt Q6P6C2
N(6)-methyladenosine in mRNA + 2-oxoglutarate + O(2) = adenosine in mRNA + formaldehyde + succinate + CO(2).
-!- Catalyzes oxidative demethylation of mRNA N(6)-methyladenine. -!- The FTO enzyme from human can also demethylate N(3)-methylthymine from single stranded DNA and N(3)-methyluridine from single stranded RNA with low activity.
|
UniProtKB Entries (1)
| Q6P6C2 |
ALKB5_HUMAN
Homo sapiens
RNA demethylase ALKBH5
|
PDB Structure
| PDB | 4O61 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
J.Biol.Chem.
|
