CATH Domain 4o0aA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.50	OB fold (Dihydrolipoamide Acetyltransferase, E2P)
	2.40.50.140	Nucleic acid-binding proteins

Domain Context

CATH Clusters

Superfamily	Nucleic acid-binding proteins
Functional Family	Replication protein A subunit

Enzyme Information

UniProtKB Entries (1)

RFA1_HUMAN

Homo sapiens

Replication protein A 70 kDa DNA-binding subunit

PDB Structure

PDB	4O0A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a potent inhibitor of replication protein a protein-protein interactions using a fragment-linking approach. Frank, A.O., Feldkamp, M.D., Kennedy, J.P., Waterson, A.G., Pelz, N.F., Patrone, J.D., Vangamudi, B., Camper, D.V., Rossanese, O.W., Chazin, W.J., Fesik, S.W. J. Med. Chem.