CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.11950 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.11950 |
| Functional Family | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase |
Enzyme Information
| 2.7.4.24 |
Diphosphoinositol-pentakisphosphate kinase.
based on mapping to UniProt O43314
(1) ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate. (2) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.
-!- This enzyme is activated by osmotic shock. -!- Ins(1,3,4,5,6)P(5), 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates. -!- Formerly EC 2.7.1.155.
|
| 2.7.4.21 |
Inositol-hexakisphosphate kinase.
based on mapping to UniProt O43314
(1) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. (2) ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
-!- Three mammalian isoforms are known to exist. -!- Formerly EC 2.7.1.152.
|
UniProtKB Entries (1)
| O43314 |
VIP2_HUMAN
Homo sapiens
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
|
PDB Structure
| PDB | 4NZN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery.
Chem.Biol.
|