CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.210 | Beta Polymerase; domain 3 |
|
3.30.210.10 | DNA polymerase, thumb domain |
Domain Context
CATH Clusters
| Superfamily | DNA polymerase, thumb domain |
| Functional Family | DNA polymerase beta |
Enzyme Information
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P06746
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
| 4.2.99.- |
Other carbon-oxygen lyases.
based on mapping to UniProt P06746
|
UniProtKB Entries (1)
| P06746 |
DPOLB_HUMAN
Homo sapiens
DNA polymerase beta
|
PDB Structure
| PDB | 4NY8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc.
|
