CATH Domain 4ny0A02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.80	Acyl-CoA Binding Protein
	1.20.80.10

Domain Context

CATH Clusters

Superfamily	1.20.80.10
Functional Family	Protein-tyrosine kinase 2-beta isoform 1

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q05397

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q05397

FAK1_HUMAN

Homo sapiens

Focal adhesion kinase 1

PDB Structure

PDB	4NY0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	FAK dimerization controls its kinase-dependent functions at focal adhesions. Brami-Cherrier, K., Gervasi, N., Arsenieva, D., Walkiewicz, K., Boutterin, M.C., Ortega, A., Leonard, P.G., Seantier, B., Gasmi, L., Bouceba, T., Kadare, G., Girault, J.A., Arold, S.T. Embo J.