CATH Domain 4nwkA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

A8DG50_9HEPC

Hepatitis C virus subtype 1a

Genome polyprotein

PDB Structure

PDB	4NWK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. Scola, P.M., Wang, A.X., Good, A.C., Sun, L.Q., Combrink, K.D., Campbell, J.A., Chen, J., Tu, Y., Sin, N., Venables, B.L., Sit, S.Y., Chen, Y., Cocuzza, A., Bilder, D.M., D'Andrea, S., Zheng, B., Hewawasam, P., Ding, M., Thuring, J., Li, J., Hernandez, D., Yu, F., Falk, P., Zhai, G., Sheaffer, A.K., Chen, C., Lee, M.S., Barry, D., Knipe, J.O., Li, W., Han, Y.H., Jenkins, S., Gesenberg, C., Gao, Q., Sinz, M.W., Santone, K.S., Zvyaga, T., Rajamani, R., Klei, H.E., Colonno, R.J., Grasela, D.M., Hughes, E., Chien, C., Adams, S., Levesque, P.C., Li, D., Zhu, J., Meanwell, N.A., McPhee, F. J.Med.Chem.