CATH Domain 4nq6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.60	4-Layer Sandwich
	3.60.15	Metallo-beta-lactamase; Chain A
	3.60.15.10	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Context

CATH Clusters

Superfamily	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt P04190

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P04190

BLA2_BACCE

Bacillus cereus

Metallo-beta-lactamase type 2

PDB Structure

PDB	4NQ6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes. Hinchliffe, P., Gonzalez, M.M., Mojica, M.F., Gonzalez, J.M., Castillo, V., Saiz, C., Kosmopoulou, M., Tooke, C.L., Llarrull, L.I., Mahler, G., Bonomo, R.A., Vila, A.J., Spencer, J. Proc. Natl. Acad. Sci. U.S.A.