CATH Domain 4npwA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family

3.1.4.17

3',5'-cyclic-nucleotide phosphodiesterase.

based on mapping to UniProt Q01064

Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.

-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

PDE1B_HUMAN

Homo sapiens

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

PDB	4NPW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1 Humphrey, J.M., Yang, E.X., Am Ende, C.W., Arnold, E.P., Head, J.L., Jenkinsonb, S., Lebel, L.A., Liras, S., Pandit, J., Samas, B., Vajdos, F., Simons, S.P., Evdokimova, A., Mansour, M., Menniti, F.S. MEDCHEMCOMM