CATH Classification
Domain Context
CATH Clusters
Superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
Functional Family | Phosphodiesterase |
Enzyme Information
3.1.4.17 |
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q01064
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
|
UniProtKB Entries (1)
Q01064 |
PDE1B_HUMAN
Homo sapiens
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
|
PDB Structure
PDB | 4NPV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1
MEDCHEMCOMM
|