CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q01064
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

UniProtKB Entries (1)

Q01064
PDE1B_HUMAN
Homo sapiens
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

PDB Structure

PDB 4NPV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1
Humphrey, J.M., Yang, E.X., Am Ende, C.W., Arnold, E.P., Head, J.L., Jenkinsonb, S., Lebel, L.A., Liras, S., Pandit, J., Samas, B., Vajdos, F., Simons, S.P., Evdokimova, A., Mansour, M., Menniti, F.S.
MEDCHEMCOMM