CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q9PM80
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q9PM80
RPOA_CAMJE
Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
DNA-directed RNA polymerase subunit alpha

PDB Structure

PDB 4NOI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
2.17 Angstrom Crystal Structure of DNA-directed RNA Polymerase Subunit Alpha from Campylobacter jejuni.
Minasov, G., Shuvalova, L., Dubrovska, I., Winsor, J., Grimshaw, S., Kwon, K., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
TO BE PUBLISHED
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