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1 keywords

CATH Domain 4njtB00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Gag-Pol polyprotein

Enzyme Information

UniProtKB Entries (1)

Q9J006
Q9J006_9HIV1
Human immunodeficiency virus 1
Protease

PDB Structure

PDB 4NJT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV.
Yedidi, R.S., Garimella, H., Aoki, M., Aoki-Ogata, H., Desai, D.V., Chang, S.B., Davis, D.A., Fyvie, W.S., Kaufman, J.D., Smith, D.W., Das, D., Wingfield, P.T., Maeda, K., Ghosh, A.K., Mitsuya, H.
Antimicrob.Agents Chemother.
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