CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family | 7-carboxy-7-deazaguanine synthase |
Enzyme Information
| 4.3.99.3 |
7-carboxy-7-deazaguanine synthase.
based on mapping to UniProt A0A0H3KB22
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3).
-!- The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes. -!- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. -!- The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. -!- The reaction is part of the biosynthesis pathway of queuosine.
|
UniProtKB Entries (1)
| A0A0H3KB22 |
QUEE_BURM1
Burkholderia multivorans ATCC 17616
7-carboxy-7-deazaguanine synthase
|
PDB Structure
| PDB | 4NJI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.
Nat.Chem.Biol.
|
