CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt Q13627
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13627
DYR1A_HUMAN
Homo sapiens
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB Structure

PDB 4NCT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine.
Alexeeva, M., Aberg, E., Engh, R.A., Rothweiler, U.
Acta Crystallogr.,Sect.D
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