CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase |
Enzyme Information
| 4.2.99.20 |
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.
based on mapping to UniProt P37355
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.
-!- Involved in the biosynthesis of vitamin K2 (menaquinone). -!- In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival. -!- It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9 were carried out by a single enzyme but this has since been disproved. -!- Formerly EC 2.5.1.64 and EC 4.2.99.n1.
|
UniProtKB Entries (1)
| P37355 |
MENH_ECOLI
Escherichia coli K-12
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
|
PDB Structure
| PDB | 4MXD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular Basis of the General Base Catalysis of an alpha/beta-Hydrolase Catalytic Triad
J.Biol.Chem.
|
