CATH Classification
Domain Context
CATH Clusters
| Superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Functional Family | Phosphodiesterase 10A |
Enzyme Information
| 3.1.4.17 |
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q9Y233
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
|
| 3.1.4.35 |
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt Q9Y233
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
|
UniProtKB Entries (1)
| Q9Y233 |
PDE10_HUMAN
Homo sapiens
CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
|
PDB Structure
| PDB | 4MS0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Identification and optimization of PDE10A inhibitors using fragment-based screening by nanocalorimetry and X-ray crystallography.
J Biomol Screen
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