CATH Domain 4mrcA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.180	Transthyretin/hydroxyisourate hydrolase domain

Domain Context

CATH Clusters

Superfamily	Transthyretin/hydroxyisourate hydrolase domain
Functional Family	Transthyretin

Enzyme Information

UniProtKB Entries (1)

TTHY_HUMAN

Homo sapiens

Transthyretin

PDB Structure

PDB	4MRC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis. Mangione, P.P., Porcari, R., Gillmore, J.D., Pucci, P., Monti, M., Porcari, M., Giorgetti, S., Marchese, L., Raimondi, S., Serpell, L.C., Chen, W., Relini, A., Marcoux, J., Clatworthy, I.R., Taylor, G.W., Tennent, G.A., Robinson, C.V., Hawkins, P.N., Stoppini, M., Wood, S.P., Pepys, M.B., Bellotti, V. Proc.Natl.Acad.Sci.USA