CATH Domain 4mq1B01

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

2.7.12.1

Dual-specificity kinase.

based on mapping to UniProt Q13627

ATP + a protein = ADP + a phosphoprotein.

-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

DYR1A_HUMAN

Homo sapiens

Dual specificity tyrosine-phosphorylation-regulated kinase 1A

PDB	4MQ1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Anderson, K., Chen, Y., Chen, Z., Dominique, R., Glenn, K., He, Y., Janson, C., Luk, K.C., Lukacs, C., Polonskaia, A., Qiao, Q., Railkar, A., Rossman, P., Sun, H., Xiang, Q., Vilenchik, M., Wovkulich, P., Zhang, X. Bioorg.Med.Chem.Lett.