CATH Domain 4motA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family	DNA gyrase subunit B

Enzyme Information

UniProtKB Entries (1)

Q8DQB5_STRR6

Streptococcus pneumoniae R6

DNA topoisomerase 4 subunit B

PDB Structure

PDB	4MOT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Thiazolopyridone ureas as DNA gyrase B inhibitors: Optimization of antitubercular activity and efficacy. Kale, R.R., Kale, M.G., Waterson, D., Raichurkar, A., Hameed, S.P., Manjunatha, M.R., Kishore Reddy, B.K., Malolanarasimhan, K., Shinde, V., Koushik, K., Jena, L.K., Menasinakai, S., Humnabadkar, V., Madhavapeddi, P., Basavarajappa, H., Sharma, S., Nandishaiah, R., Mahesh Kumar, K.N., Ganguly, S., Ahuja, V., Gaonkar, S., Naveen Kumar, C.N., Ogg, D., Boriack-Sjodin, P.A., Sambandamurthy, V.K., de Sousa, S.M., Ghorpade, S.R. Bioorg.Med.Chem.Lett.