CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.390 | FMN-linked oxidoreductases |
Domain Context
CATH Clusters
| Superfamily | FMN-linked oxidoreductases |
| Functional Family | Heptaprenylglyceryl phosphate synthase |
Enzyme Information
| 2.5.1.41 |
Phosphoglycerol geranylgeranyltransferase.
based on mapping to UniProt O26652
Geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate.
-!- Catalyzes the first pathway-specific step in the biosynthesis of the core membrane diether lipids in archaebacteria. -!- It catalyzes the alkylation of the primary hydroxy group in sn-glycerol 1-phosphate by geranylgeranyl diphosphate (GGPP) in a prenyltransfer reaction where a hydroxy group is the nucleophile in the acceptor substrate. -!- The other enzymes involved in the biosynthesis of polar lipids in archaea are EC 1.1.1.261, EC 2.5.1.42 and EC 2.7.7.67, which lead to the formation of CDP-unsaturated archaeol. -!- The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine.
|
UniProtKB Entries (1)
| O26652 |
GGGPS_METTH
Methanothermobacter thermautotrophicus str. Delta H
Geranylgeranylglyceryl phosphate synthase
|
PDB Structure
| PDB | 4MM1 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.
Mol.Microbiol.
|