CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.367.20
Functional Family Hexokinase 1

Enzyme Information

2.7.1.2
Glucokinase.
based on mapping to UniProt P35557
ATP + D-glucose = ADP + D-glucose 6-phosphate.
-!- A group of enzymes found in invertebrates and microorganisms highly specific for glucose.

UniProtKB Entries (1)

P35557
HXK4_HUMAN
Homo sapiens
Glucokinase

PDB Structure

PDB 4MLE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification of a New Class of Glucokinase Activators through Structure-Based Design.
Hinklin, R.J., Boyd, S.A., Chicarelli, M.J., Condroski, K.R., Dewolf, W.E., Lee, P.A., Lee, W., Singh, A., Thomas, L., Voegtli, W.C., Williams, L., Aicher, T.D.
J.Med.Chem.