CATH Classification

Domain Context

CATH Clusters

Superfamily SET domain
Functional Family Putative histone-lysine N-methyltransferase EZH2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q15910
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q15910
EZH2_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase EZH2

PDB Structure

PDB 4MI0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Wu, H., Zeng, H., Dong, A., Li, F., He, H., Senisterra, G., Seitova, A., Duan, S., Brown, P.J., Vedadi, M., Arrowsmith, C.H., Schapira, M.
Plos One