CATH Domain 4mdkE00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.20	Ubiquitin-like (UB roll)
	3.10.20.90	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Functional Family	Polyubiquitin-C

Enzyme Information

UniProtKB Entries (1)

UB2R1_HUMAN

Homo sapiens

Ubiquitin-conjugating enzyme E2 R1

PDB Structure

PDB	4MDK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Huang, H., Ceccarelli, D.F., Orlicky, S., St-Cyr, D.J., Ziemba, A., Garg, P., Plamondon, S., Auer, M., Sidhu, S., Marinier, A., Kleiger, G., Tyers, M., Sicheri, F. Nat.Chem.Biol.