CATH Domain 4mdeA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information

UniProtKB Entries (1)

A3DJ38_CLOTH

Hungateiclostridium thermocellum ATCC 27405

Metallophosphoesterase

PDB Structure

PDB	4MDE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structures of bacterial polynucleotide kinase in a Michaelis complex with GTPMg2+ and 5'-OH oligonucleotide and a product complex with GDPMg2+ and 5'-PO4 oligonucleotide reveal a mechanism of general acid-base catalysis and the determinants of phosphoacceptor recognition. Das, U., Wang, L.K., Smith, P., Jacewicz, A., Shuman, S. Nucleic Acids Res.