CATH Domain 4mcdA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1270	Trp Operon Repressor; Chain A
	1.10.1270.20	tRNA(m1g37)methyltransferase, domain 2

Domain Context

CATH Clusters

Superfamily	tRNA(m1g37)methyltransferase, domain 2
Functional Family	tRNA (guanine-N(1)-)-methyltransferase

Enzyme Information

2.1.1.228

tRNA (guanine(37)-N(1))-methyltransferase.

based on mapping to UniProt P43912

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

P43912

TRMD_HAEIN

Haemophilus influenzae Rd KW20

TRNA (guanine-N(1)-)-methyltransferase

PDB Structure

PDB	4MCD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain. Hill, P.J., Abibi, A., Albert, R., Andrews, B., Gagnon, M.M., Gao, N., Grebe, T., Hajec, L.I., Huang, J., Livchak, S., Lahiri, S.D., McKinney, D.C., Thresher, J., Wang, H., Olivier, N., Buurman, E.T. J.Med.Chem.