CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.600 | Farnesyl Diphosphate Synthase |
|
1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
| Superfamily | Farnesyl Diphosphate Synthase |
| Functional Family | (2Z,6E)-hedycaryol synthase |
Enzyme Information
| 4.2.3.187 |
(2Z,6E)-hedycaryol synthase.
based on mapping to UniProt E4MYY0
(2E,6E)-farnesyl diphosphate + H(2)O = (2Z,6E)-hedycaryol + diphosphate.
-!- Isolated from the bacterium Kitasatospora setae. -!- The stereochemistry suggests the farnesyl diphosphate rearranges to nerolidyl diphosphate or an equivalent intermediate before cyclization. -!- See also EC 4.2.3.174.
|
UniProtKB Entries (1)
| E4MYY0 |
HCS_KITSK
Kitasatospora setae KM-6054
(2Z,6E)-hedycaryol synthase
|
PDB Structure
| PDB | 4MC8 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism.
Chembiochem
|
