CATH Domain 4m7yA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Domain Context

CATH Clusters

Superfamily	3.30.420.40
Functional Family	Type II pantothenate kinase

Enzyme Information

2.7.1.33

Pantothenate kinase.

based on mapping to UniProt Q8NVG0

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

UniProtKB Entries (1)

COAW_STAAW

Staphylococcus aureus subsp. aureus MW2

Type II pantothenate kinase

PDB Structure

PDB	4M7Y
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. Hughes, S.J., Barnard, L., Mottaghi, K., Tempel, W., Antoshchenko, T., Hong, B.S., Allali-Hassani, A., Smil, D., Vedadi, M., Strauss, E., Park, H.W. ACS Infect Dis