CATH Domain 4m74A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.10	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Domain Context

CATH Clusters

Superfamily	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family

Enzyme Information

2.1.1.281

Phenylpyruvate C(3)-methyltransferase.

based on mapping to UniProt Q643C8

S-adenosyl-L-methionine + 3-phenylpyruvate = S-adenosyl-L-homocysteine + (3S)-2-oxo-3-phenylbutanoate.

-!- The enzyme from the bacterium Streptomyces hygroscopicus NRRL3085 is involved in synthesis of the nonproteinogenic amino acid (2S,3S)- beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.

UniProtKB Entries (1)

Q643C8

MPPJ_STRHY

Streptomyces hygroscopicus

Phenylpyruvate C(3)-methyltransferase

PDB Structure

PDB	4M74
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase Zou, X.W., Liu, Y.C., Hsu, N.S., Huang, C.J., Lyu, S.Y., Chan, H.C., Chang, C.Y., Yeh, H.W., Lin, K.H., Wu, C.J., Tsai, M.D., Li, T.L. Acta Crystallogr.,Sect.D