CATH Domain 4m1uA02

CATH Classification

Level	CATH Code	Description
	4	Few Secondary Structures
	4.10	Irregular
	4.10.470	Ricin (A Subunit), domain 2
	4.10.470.10	Ricin (A Subunit), domain 2

Domain Context

CATH Clusters

Superfamily	Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt Q7DI68

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (2)

Q7DJJ2	Q7DJJ2_ECOLX Escherichia coli Shiga toxin 2 B subunit
Q7DI68	Q7DI68_ECO57 Escherichia coli O157:H7 Shiga toxin 2 A-subunit

PDB Structure

PDB	4M1U
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The crystal structure of shiga toxin type 2 with bound disaccharide guides the design of a heterobifunctional toxin inhibitor. Jacobson, J.M., Yin, J., Kitov, P.I., Mulvey, G., Griener, T.P., James, M.N., Armstrong, G., Bundle, D.R. J.Biol.Chem.