CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.450 | EAL domain |
Domain Context
CATH Clusters
| Superfamily | EAL domain |
| Functional Family | Cyclic di-GMP phosphodiesterase yahA |
Enzyme Information
| 3.1.4.52 |
Cyclic-guanylate-specific phosphodiesterase.
based on mapping to UniProt P21514
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
-!- Inhibited by Ca(2+) and Zn(2+). -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive. -!- It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.
|
UniProtKB Entries (1)
| P21514 |
PDEL_ECOLI
Escherichia coli K-12
Cyclic di-GMP phosphodiesterase PdeL
|
PDB Structure
| PDB | 4LYK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Inherent Regulation of EAL Domain-catalyzed Hydrolysis of Second Messenger Cyclic di-GMP.
J.Biol.Chem.
|
