CATH Classification
Level | CATH Code | Description |
---|---|---|
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3 | Alpha Beta |
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3.20 | Alpha-Beta Barrel |
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3.20.20 | TIM Barrel |
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3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
Superfamily | Aldolase class I |
Functional Family |
Enzyme Information
2.4.2.12 |
Nicotinamide phosphoribosyltransferase.
based on mapping to UniProt P43490
Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.
|
UniProtKB Entries (1)
P43490 |
NAMPT_HUMAN
Homo sapiens
Nicotinamide phosphoribosyltransferase
|
PDB Structure
PDB | 4LV9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett.
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