CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 12

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt Q9ULX7
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

Q9ULX7
CAH14_HUMAN
Homo sapiens
Carbonic anhydrase 14

PDB Structure

PDB 4LU3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors.
Alterio, V., Pan, P., Parkkila, S., Buonanno, M., Supuran, C.T., Monti, S.M., De Simone, G.
Biopolymers