CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1410.10
Functional Family

Enzyme Information

2.7.7.19
Polynucleotide adenylyltransferase.
based on mapping to UniProt Q9BWT3
ATP + RNA(n) = diphosphate + RNA(n+1).
-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

Q9BWT3
PAPOG_HUMAN
Homo sapiens
Poly(A) polymerase gamma

PDB Structure

PDB 4LT6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases.
Yang, Q., Nausch, L.W., Martin, G., Keller, W., Doublie, S.
J.Mol.Biol.