CATH Domain 4lt6A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.460	Beta Polymerase; domain 2
	3.30.460.10	Beta Polymerase, domain 2

Domain Context

CATH Clusters

Superfamily	Beta Polymerase, domain 2
Functional Family	Poly(A) polymerase alpha, putative

Enzyme Information

2.7.7.19

Polynucleotide adenylyltransferase.

based on mapping to UniProt Q9BWT3

ATP + RNA(n) = diphosphate + RNA(n+1).

-!- Also acts slowly with CTP. -!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- The primer, depending on the source of the enzyme, may be an RNA or DNA fragment or oligo(A) bearing a 3'-OH terminal group. -!- See also EC 2.7.7.6.

UniProtKB Entries (1)

Q9BWT3

PAPOG_HUMAN

Homo sapiens

Poly(A) polymerase gamma

PDB Structure

PDB	4LT6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of human poly(a) polymerase gamma reveals a conserved catalytic core for canonical poly(a) polymerases. Yang, Q., Nausch, L.W., Martin, G., Keller, W., Doublie, S. J.Mol.Biol.