CATH Domain 4lpbA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.565	Heat Shock Protein 90
	3.30.565.10	Histidine kinase-like ATPase, C-terminal domain

Domain Context

CATH Clusters

Superfamily	Histidine kinase-like ATPase, C-terminal domain
Functional Family	DNA gyrase subunit B

Enzyme Information

UniProtKB Entries (1)

Q8DQB5_STRR6

Streptococcus pneumoniae R6

DNA topoisomerase 4 subunit B

PDB Structure

PDB	4LPB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-to-Hit-to-Lead Discovery of a Novel Pyridylurea Scaffold of ATP Competitive Dual Targeting Type II Topoisomerase Inhibiting Antibacterial Agents. Basarab, G.S., Manchester, J.I., Bist, S., Boriack-Sjodin, P.A., Dangel, B., Illingworth, R., Sherer, B.A., Sriram, S., Uria-Nickelsen, M., Eakin, A.E. J.Med.Chem.