CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.290 | Spermadhesin, CUB domain |
Domain Context
CATH Clusters
| Superfamily | Spermadhesin, CUB domain |
| Functional Family | complement C1s subcomponent |
Enzyme Information
| 3.4.21.42 |
Complement subcomponent C1s.
based on mapping to UniProt P09871
Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.
-!- Activated from proenzyme C1s in plasma by the activated complement subcomponent C1r. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P09871 |
C1S_HUMAN
Homo sapiens
Complement C1s subcomponent
|
PDB Structure
| PDB | 4LOR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
Proc.Natl.Acad.Sci.USA
|
