CATH Domain 4lgrA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.420	Ricin (A subunit); domain 1
	3.40.420.10	Ricin (A subunit), domain 1

Domain Context

CATH Clusters

Superfamily	Ricin (A subunit), domain 1
Functional Family	Ricin

Enzyme Information

3.2.2.22

rRNA N-glycosylase.

based on mapping to UniProt P02879

Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P02879

RICI_RICCO

Ricinus communis

Ricin

PDB Structure

PDB	4LGR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structures of Ricin Toxin's Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-Neutralizing Single-Chain Antibodies. Rudolph, M.J., Vance, D.J., Cheung, J., Franklin, M.C., Burshteyn, F., Cassidy, M.S., Gary, E.N., Herrera, C., Shoemaker, C.B., Mantis, N.J. J.Mol.Biol.