CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family |
Enzyme Information
1.1.1.369 |
D-chiro-inositol 1-dehydrogenase.
based on mapping to UniProt P26935
1D-chiro-inositol + NAD(+) = 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH.
-!- The enzyme, found in the bacterium Bacillus subtilis, also catalyzes the reaction of EC 1.1.1.18 and can also use D-glucose and D-xylose. -!- It shows trace activity with D-ribose and D-fructose. -!- It is part of a myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA. -!- Formerly EC 1.1.1.n6.
|
1.1.1.18 |
Inositol 2-dehydrogenase.
based on mapping to UniProt P26935
Myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + NADH.
|
UniProtKB Entries (1)
P26935 |
IOLG_BACSU
Bacillus subtilis subsp. subtilis str. 168
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
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PDB Structure
PDB | 4L8V |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Converting NAD-Specific Inositol Dehydrogenase to an Efficient NADP-Selective Catalyst, with a Surprising Twist.
Biochemistry
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