CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.580 | CBS-domain |
|
3.10.580.10 | CBS-domain |
Domain Context
CATH Clusters
| Superfamily | CBS-domain |
| Functional Family | Cystathionine beta-synthase |
Enzyme Information
| 4.2.1.22 |
Cystathionine beta-synthase.
based on mapping to UniProt P35520
L-serine + L-homocysteine = L-cystathionine + H(2)O.
-!- A multifunctional enzyme: catalyzes beta-replacement reaction between L-serine, L-cysteine, cysteine thioethers or some other beta- substituted alpha-L-amino acids and a variety of mercaptans. -!- Formerly EC 4.2.1.21.
|
UniProtKB Entries (1)
| P35520 |
CBS_HUMAN
Homo sapiens
Cystathionine beta-synthase
|
PDB Structure
| PDB | 4L3V |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration.
Proc.Natl.Acad.Sci.USA
|
