CATH Domain 4l02A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.200	Tumour Suppressor Smad4
	2.60.200.40

Domain Context

CATH Clusters

Superfamily	2.60.200.40
Functional Family	Sphingosine kinase 1

Enzyme Information

2.7.1.91

Sphingosine kinase.

based on mapping to UniProt Q9NYA1

ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.

-!- The enzyme is involved in the production of sphingolipid metabolites. -!- It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine. -!- The exact substrate range depends on the species.

2.3.1.-

Transferring groups other than amino-acyl groups.

based on mapping to UniProt Q9NYA1

UniProtKB Entries (1)

Q9NYA1

SPHK1_HUMAN

Homo sapiens

Sphingosine kinase 1

PDB Structure

PDB	4L02
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Gustin, D.J., Li, Y., Brown, M.L., Min, X., Schmitt, M.J., Wanska, M., Wang, X., Connors, R., Johnstone, S., Cardozo, M., Cheng, A.C., Jeffries, S., Franks, B., Li, S., Shen, S., Wong, M., Wesche, H., Xu, G., Carlson, T.J., Plant, M., Morgenstern, K., Rex, K., Schmitt, J., Coxon, A., Walker, N., Kayser, F., Wang, Z. Bioorg.Med.Chem.Lett.