CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1260.10
Functional Family

Enzyme Information

4.1.99.5
Aldehyde oxygenase (deformylating).
based on mapping to UniProt Q7V6D4
A long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+).
-!- Involved in the biosynthesis of alkanes. -!- The enzyme from the cyanobacterium Nostoc punctiforme PCC 73102 is only active in vitro in the presence of ferredoxin, ferredoxin reductase and NADPH, and produces mostly C(15) to C(17) alkanes. -!- The enzyme from pea (Pisum sativum) produces alkanes of chain length C18 to C32 and is inhibited by metal-chelating agents. -!- The substrate for this enzyme is formed by EC 1.2.1.80.

UniProtKB Entries (1)

Q7V6D4
ALDEC_PROMM
Prochlorococcus marinus str. MIT 9313
Aldehyde decarbonylase

PDB Structure

PDB 4KVS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Production of propane and other short-chain alkanes by structure-based engineering of ligand specificity in aldehyde-deformylating oxygenase.
Khara, B., Menon, N., Levy, C., Mansell, D., Das, D., Marsh, E.N., Leys, D., Scrutton, N.S.
Chembiochem