CATH Domain 4krsA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.228	Phosphoenolpyruvate Carboxykinase; domain 3
	3.90.228.10

Domain Context

CATH Clusters

Superfamily	3.90.228.10
Functional Family	Poly [ADP-ribose] polymerase tankyrase-2

Enzyme Information

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt O95271

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt O95271

UniProtKB Entries (1)

O95271

TNKS1_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase tankyrase-1

PDB Structure

PDB	4KRS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Efficiency Relationship of [1,2,4]Triazol-3-ylamines as Novel Nicotinamide Isosteres that Inhibit Tankyrases. Shultz, M.D., Majumdar, D., Chin, D.N., Fortin, P.D., Feng, Y., Gould, T., Kirby, C.A., Stams, T., Waters, N.J., Shao, W. J.Med.Chem.