CATH Domain 4kqrA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.4.16.4

Serine-type D-Ala-D-Ala carboxypeptidase.

based on mapping to UniProt G3XD46

Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.

-!- A group of bacterial enzymes, membrane-bound. -!- Inhibited by beta-lactam antibiotics, which acylate the active site serine in the enzyme. -!- Distinct from EC 3.4.17.14. -!- Belongs to peptidase families S11, S12 and S13.

UniProtKB Entries (1)

G3XD46

FTSI_PSEAE

Pseudomonas aeruginosa PAO1

Peptidoglycan D,D-transpeptidase FtsI

PDB Structure

PDB	4KQR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3. van Berkel, S.S., Nettleship, J.E., Leung, I.K., Brem, J., Choi, H., Stuart, D.I., Claridge, T.D., McDonough, M.A., Owens, R.J., Ren, J., Schofield, C.J. Acs Chem.Biol.