CATH Classification

Domain Context

CATH Clusters

Superfamily Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family Possible thymidylate synthase

Enzyme Information

2.1.1.45
Thymidylate synthase.
based on mapping to UniProt P04818
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

P04818
TYSY_HUMAN
Homo sapiens
Thymidylate synthase

PDB Structure

PDB 4KPW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
Salo-Ahen, O.M., Tochowicz, A., Pozzi, C., Cardinale, D., Ferrari, S., Boum, Y., Mangani, S., Stroud, R.M., Saxena, P., Myllykallio, H., Costi, M.P., Ponterini, G., Wade, R.C.
J.Med.Chem.