CATH Domain 4kp8A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.200	Carbonic Anhydrase II
	3.10.200.10	Alpha carbonic anhydrase

Domain Context

CATH Clusters

Superfamily	Alpha carbonic anhydrase
Functional Family	Carbonic anhydrase 12

Enzyme Information

4.2.1.1

Carbonic anhydrase.

based on mapping to UniProt O43570

H(2)CO(3) = CO(2) + H(2)O.

-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

O43570

CAH12_HUMAN

Homo sapiens

Carbonic anhydrase 12

PDB Structure

PDB	4KP8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII Capkauskaite, E., Zubriene, A., Smirnov, A., Torresan, J., Kisonaite, M., Kazokaite, J., Gylyte, J., Michailoviene, V., Jogaite, V., Manakova, E., Grazulis, S., Tumkevicius, S., Matulis, D. Bioorg.Med.Chem.