CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.270 | Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; Domain 6 |
|
2.40.270.10 | DNA-directed RNA polymerase, subunit 2, domain 6 |
Domain Context
CATH Clusters
| Superfamily | DNA-directed RNA polymerase, subunit 2, domain 6 |
| Functional Family | DNA-directed RNA polymerase subunit beta |
Enzyme Information
| 2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P0A8V2
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
|
UniProtKB Entries (1)
| P00579 |
RPOD_ECOLI
Escherichia coli K-12
RNA polymerase sigma factor RpoD
|
PDB Structure
| PDB | 4KN7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray Crystal Structures of the Escherichia coli RNA Polymerase in Complex with Benzoxazinorifamycins.
J.Med.Chem.
|
