CATH Domain 4klbA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Cruzipain

Enzyme Information

3.4.22.51

Cruzipain.

based on mapping to UniProt P25779

Broad endopeptidase specificity similar to that of cathepsin L.

-!- Is located in the digestive vacuoles of the parasitic trypanosome and contributes to the nutrition of the organism by digestion of host proteins. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P25779

CYSP_TRYCR

Trypanosoma cruzi

Cruzipain

PDB Structure

PDB	4KLB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay. Wiggers, H.J., Rocha, J.R., Fernandes, W.B., Sesti-Costa, R., Carneiro, Z.A., Cheleski, J., da Silva, A.B., Juliano, L., Cezari, M.H., Silva, J.S., McKerrow, J.H., Montanari, C.A. Plos Negl Trop Dis