1 keywords

CATH Domain 4kl1D02

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.10 Jelly Rolls

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Enzyme Information

UniProtKB Entries (1)

Q9Y3Q4
HCN4_HUMAN
Homo sapiens
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

PDB Structure

PDB 4KL1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Lolicato, M., Bucchi, A., Arrigoni, C., Zucca, S., Nardini, M., Schroeder, I., Simmons, K., Aquila, M., DiFrancesco, D., Bolognesi, M., Schwede, F., Kashin, D., Fishwick, C.W., Johnson, A.P., Thiel, G., Moroni, A.
Nat.Chem.Biol.