1 keywords

CATH Domain 4kl1B01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.287 Helix Hairpins
Homologous Superfamily 1.10.287.630 Helix hairpin bin

Domain Context

CATH Clusters

Superfamily Helix hairpin bin
Functional Family Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Enzyme Information

UniProtKB Entries (1)

Q9Y3Q4
HCN4_HUMAN
Homo sapiens
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

PDB Structure

PDB 4KL1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Lolicato, M., Bucchi, A., Arrigoni, C., Zucca, S., Nardini, M., Schroeder, I., Simmons, K., Aquila, M., DiFrancesco, D., Bolognesi, M., Schwede, F., Kashin, D., Fishwick, C.W., Johnson, A.P., Thiel, G., Moroni, A.
Nat.Chem.Biol.